Increased mucosal eosinophils in colonic diverticulosis and diverticular disease.

AIMS: Eosinophils contribute to tissue homeostasis, damage, and repair. The mucosa of colonic diverticula has not been evaluated for eosinophils by quantitative histology. We aimed to investigate whether mucosal eosinophils and other immune cells are increased in colonic diverticula. METHODS: Hematoxylin and eosin stained sections from colonic surgical resections (n = 82) containing diverticula were examined. Eosinophils, neutrophils, and lymphocytes, in five high power fields in the lamina propria were counted at the base, neck, and ostia of the diverticulum and counts compared to non-diverticula mucosa. The cohort was further subgrouped by elective and emergency surgical indications. RESULTS: Following an initial review of 10 surgical resections from patients with diverticulosis, a total of 82 patients with colonic resections containing diverticula from the descending colon were evaluated (median age 71.5, 42 M/40F). Eosinophil counts for the entire cohort were increased in the base and neck (median 99 and 42, both P = <0.001) compared with the control location (median 16). Eosinophil counts remained significantly increased in the diverticula base (both P = <0.001) and neck (P = 0.01 and <0.001, respectively) in both elective and emergency cases. Lymphocytes were also significantly increased at the diverticula base compared to controls in both elective and emergency subgroups. CONCLUSION: Eosinophils are significantly and most strikingly increased within the diverticulum in resected colonic diverticula. While these observations are novel, the role of eosinophil and chronic inflammation is as yet unclear in the pathophysiology of colonic diverticulosis and diverticular disease.

Outcomes of surgical treatment of diverticular abscesses after failure of antibiotic therapy.

Management of diverticular abscess (DA) is still controversial. Antibiotic therapy is indicated in abscesses ≤ 4 cm, while percutaneous drainage/surgery in abscesses > 4 cm. The study aims to assess the role of antibiotics and surgical treatments in patients affected by DA. We retrospectively analyzed 100 consecutive patients with DA between 2013 and 2020, with a minimum follow-up of 12 months. They were divided into two groups depending on abscess size ≤ or > 4 cm (group 1 and group 2, respectively). All patients were initially treated with intravenous antibiotics. Surgery was considered in patients with generalized peritonitis at admission or after the failure of antibiotic therapy. The primary endpoint was to compare recurrence rates for antibiotics and surgery. The secondary endpoint was to assess the failure rate of each antibiotic regimen resulting in surgery. In group 1, 31 (72.1%) patients were conservatively treated and 12 (27.9%) underwent surgery. In group 2, percentages were respectively 50.9% (29 patients) and 49.1% (28 patients). We observed 4 recurrences in group 1 and 6 in group 2. Recurrence required surgery in 3 patients/group. We administered amoxicillin-clavulanic acid to 74 patients, piperacillin-tazobactam to 14 patients and ciprofloxacin + metronidazole to 12 patients. All patients referred to surgery had been previously treated with amoxicillin-Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation clavulanic acid. No percutaneous drainage was performed in a hundred consecutive patients. Surgical treatment was associated with a lower risk of recurrence in patients with abscess > 4 cm, compared to antibiotics. Amoxicillin-clavulanic acid was associated with a higher therapeutic failure rate than piperacillin-tazobactam/ciprofloxacin + metronidazole.

Surgical management of colonic diverticulosis: Issues of indications, treatment options, surgical solutions / A vastagbél-diverticulosis sebészi kezelése: Javallati dilemmák, kezelési lehetoségek, mutéti megoldások

Összefoglaló. Bevezetés: A vastagbél-diverticulosis a lakosság kb. 60%-át érinti, incidenciája folyamatosan növekszik. A betegek 6%-ánál van szükség sebészi beavatkozásra. Jelenleg nincs egységes irányelv, mikor indokolt elektív mutétet végezni. Módszer: Retrospektív módszerrel elemeztük az osztályunkon 2017. július 17. és 2020. április 30. között vastagbél-diverticulosis miatt operált betegek demográfiai és mutéti adatait, emellett a szövodmények arányát. Összehasonlítottuk az elektív (EM) és a sürgos mutétek (SM), illetve a nyitott és a laparoszkópos mutétek adatait. Eredmények: 38 operált beteg közül 19-nél történt EM, illetve 19 betegnél SM. A betegek átlagéletkora az EM-eknél 64 év, az SM-ek esetében 67 év volt. EM-nél az indikáció 12 esetben recidiváló diverticulitis, 5 esetben colovesicalis, 2 esetben colovaginalis sipoly volt. SM-nél az indikáció 17 esetben perforáció, 2 esetben hasüregi tályog volt. Az EM-ek 89%-a laparoszkópos módon került elvégzésre; az átlagos mutéti ido EM/SM esetében 96 perc/89 perc, az átlagos ápolási napok száma 17/14 volt. Az EM-csoportból 1 beteg, míg az SM-csoportból 5 beteg meghalt. Szignifikáns különbség volt a mutét típusa, a stomaképzés és a transzfúziós igény tekintetében. Nem találtunk szignifikáns eltérést a posztoperatív ápolási napok és a mortalitás tekintetében. Következtetés: Az elektív mutétek alacsonyabb morbiditása és mortalitása, illetve a laparoszkópos technika alkalmazhatósága miatt törekedni kell a tervezett mutétre. Nincs egységes irányelv a relatív mutéti indikáció felállításában: gasztroenterológus és sebész által felállított, személyre szabott kezelési stratégia szükséges. Véleményünk szerint indokolt a mutét, amennyiben igazolt diverticulosis esetében szigorú diéta mellett kiújul a gyulladás. Orv Hetil. 2020; 161(51): 2146-2152. INTRODUCTION: Colonic diverticulosis affects 60% of the population, incidence of the disease grows progressively. During its course, 6% of patients with diverticulosis will need surgical intervention. There is no current guideline when to carry out elective operation. METHOD: We analyzed demographics, surgical patient data and also post-operative complications of patients operated in our department due to colonic diverticulosis between 17-07-2017 and 30-04-2020 retrospectively. We compared the results of elective (ES) and acute surgeries (AS), also laparotomies versus laparoscopies. RESULTS: 19 out of 38 patients underwent ES and 19 AS. ES group average age was 64 years, and 67 in the AS group. Indications of ES were recurring diverticulitis in 12, colovesical fistula in 5 and colovaginal fistula in 2 cases. Indications of AS were perforations in 17 and intraabdominal abscesses in 2 cases. 89% of all ES were operated laparoscopically; average operation time in ES/AS was 96/89 minutes, average hospital stay was 17/14 days. 1 patient after ES and 5 after AS died. Significant difference was found between the groups with regard to the type of operation, frequency of colostomy creation and the need of blood transfusion but no significant difference was demonstrated in average hospital stay and mortality. CONCLUSION: Due to the lower morbidity and mortality rate as well as the benefits of laparoscopic approach, we should always opt for ES. No guideline for relative surgical indication exists: gastroenterologist and surgeon should make a personalized surgical plan. In our opinion, operation should be carried out if diverticulitis reoccurs while the patient is on strict diet. Orv Hetil. 2020; 161(51): 2146-2152.

Association Between Colonic Diverticulosis and Colorectal Polyps, Advanced Neoplastic Lesions, and Colorectal Carcinomas: A Cross-Sectional, Retrospective Study.

PURPOSE: The aim of the present study was to evaluate the association of diverticulosis with colorectal polyps, advanced neoplastic lesions (ANLs), and colorectal cancers (CRCs). METHODS: The first-time colonoscopy records of 3496 patients were evaluated in this retrospective, cross-sectional cohort study. Data on clinical indications, presence of diverticulosis and diverticulitis, location of diverticula and polps, the size and number of polyps, and results of histopathologic examinations of polypectomies were noted. Categorical data were analyzed with χ test or the Fisher exact probability. P-values <0.05 (2 sided) were considered statistically significant. Statistical analyses were conducted with SPSS, version 18. RESULTS: Of the 3496 patients, 1691 were male individuals (48.4%) and 1805 (51.6%) were female individuals. Diverticulosis was present in 12.6% of patients. A total of 870 polyps were detected in 716 patients. A total of 170 polyps (19.5%) were classified as ANLs. CRC was diagnosed in 112 (3.2%) patients. A significant relationship between diverticulosis and colorectal polyps (odds ratio: 1.99; 95% confidence interval: 1.59-0.2.48, P<0.001) was found. Similarly, adenomas and ANLs were more frequent in diverticulosis (P<0.05). There was no significant relationship between diverticulosis and CRCs (P=0.243). CONCLUSIONS: Adenomatous polyps and ANLs were more frequently observed in patients with diverticulosis, but no significant relationship was found between CRC and diverticulosis. The results of this retrospective cross-sectional study need to be confirmed by longitudinal prospective cohort studies.

A curious case of colitis.

Segmental colitis associated with diverticulosis (SCAD) is a rare variant of chronic colitis that is limited to segments of the left colon that harbor diverticula. Histologically, SCAD is known to mimic chronic idiopathic inflammatory bowel disease. Patients usually present with hematochezia and cramping abdominal pain; SCAD often resolves spontaneously without treatment, or completely after a limited course of therapy. Due to the histologic overlap with ulcerative colitis and occasional Crohn colitis, the implications of an inaccurate diagnosis are significant.

Sigmoidectomy for Diverticulitis-A Propensity-Matched Comparison of Minimally Invasive Approaches.

BACKGROUND: As the availability and use of robotic surgery increases, current data suggest comparable outcomes to laparoscopic surgery but at an increased cost. Elective sigmoid resection for diverticular disease is the most common colorectal application of robotic surgery and there is limited comparative data specifically for this indication. METHODS: We identified all elective cases of laparoscopic- and robot-assisted surgery for diverticular disease among a practice of 7 colorectal surgeons within an established enhanced recovery protocol. We performed propensity matching based on surgical indications (recurrent disease, ongoing symptoms, or fistula), stoma creation, and body mass index to create a matched cohort. Our primary outcomes were return of bowel function, length of stay, opioid use, and pain scores during the first 72 h postoperatively. Secondary outcomes were operative room and hospital charges. RESULTS: From 2011 to 2016, 69 robotic cases were propensity matched from a group of 222 laparoscopic cases to create a 1:1 case ratio that was equivalent in terms of patient demographics and operative indications. Time to first bowel movement was slightly quicker in the robotic group (1 [1] versus 2 [1.5], P = 0.09), while length of stay (3.5 [1.6] versus 3.6 [1.4] d, P = 0.64) was equivalent. Pain scores were lower in the robotic group on day 0 (4.6 versus 6.1, P = 0.0001), but similar on day 1 and day 2 (4.3 versus 4.1, P = 0.62 and 3.8 versus 3.3, P = 0.19). There was no difference in postoperative 72-h opioid use between groups (110.8 MME [144.5] versus 97.4 MME [101.5], P = 0.70). In the robotic arm operating room charges were slightly more ($2835 ± $394 versus $2196 ± $359, P < 0.0001), but total hospital charges were over significantly increased ($41,159 [$7840] versus $25,761 [$11,689], P < 0.0001). CONCLUSIONS: Via a carefully matched cohort of elective sigmoid resection for diverticular disease at a single community institution, we have demonstrated that laparoscopic- and robotic-assisted surgery result in clinically equivalent return of bowel function, length of stay, postoperative pain, and opioid use.

Indocyanine green fluorescence angiography: a new ERAS item.

ERAS protocol and indocyanine green fluorescence angiography (ICG-FA) represent the new surgical revolution minimizing complications and shortening recovery time in colorectal surgery. As of today, no studies have been published in the literature evaluating the impact of the ICG-FA in the ERAS protocol for the patients suitable for colorectal surgery. The aim of our study was to assess whether the systematic evaluation of intestinal perfusion by ICG-FA could improve patients outcomes when managed with ERAS perioperative protocol, thus reducing surgical complication rate. This is a retrospective case-control study. From March 2014 to April 2017, 182 patients underwent laparoscopic colorectal surgery for benign and malignant diseases. All the patients were enrolled in ERAS protocol. Two groups were created: Group A comprehended 107 patients managed within the ERAS pathway only and Group B comprehended 75 patients managed as well as with ERAS pathway plus the intraoperative assessment of intestinal perfusion with ICG-FA. Two board-certified laparoscopic colorectal surgeons jointly performed all procedures. Six (5.6%) clinically relevant anastomotic leakages (AL) occurred in Group A, while there was none in Group B, demonstrating that ICG-FA integrated in the ERAS protocol can lead to a statistically significant reduction of the AL. Mean operative time between the two groups was not statistically significant. In five cases (6.6%), the demarcation line set by the fluorescence made the surgeon change the resection line previously marked. The prevalence of all other complications did not differ statistically between the two groups. Our study confirms that combination between ICG and ERAS protocol is feasible and safe and reduces the anastomotic leakage, possibly leading to consider ICG-FA as a new ERAS item.

[Utilidad de la proteína C reactiva en el diagnóstico oportuno de fuga de anastomosis en cirugía colorrectal]. / Utility of C-reactive protein in the early diagnosis of anastomotic leakage in colorectal surgery.

INTRODUCCIÓN: La fuga de anastomosis (FA) en cirugía colorrectal es una complicación temida por el incremento de la morbimortalidad. La tasa de FA se reporta desde el 1 hasta el 25%. Realizar el diagnóstico de forma temprana es difícil. OBJETIVO: Determinar el rendimiento diagnóstico de la proteína C reactiva (PCR) en una cohorte de pacientes sometidos a cirugía colorrectal electiva con anastomosis. MÉTODO: Se realizó un estudio prospectivo, comparativo, en 138 pacientes sometidos a cirugía colorrectal con anastomosis de forma electiva, analizando los valores séricos de la PCR los días 1, 3, 5 y 7 del posoperatorio, así como los de leucocitos y otros datos de sepsis abdominal. RESULTADOS: La tasa de FA fue del 6.5%, y los valores de la PCR fueron significativamente más altos en el grupo de pacientes con FA en el tercer día del posoperatorio. Con un punto de corte de 18.5 mg/dl en el tercer día del posoperatorio se obtuvo una sensibilidad del 81%, una especificidad del 91%, un valor predictivo positivo del 45% y un valor predictivo negativo del 98%. CONCLUSIÓN: La medición de la PCR en el tercer día del posoperatorio en pacientes sometidos a cirugía colorrectal electiva con anastomosis primaria o secundaria permite identificar las complicaciones sépticas, incluida la FA. INTRODUCTION: The anastomotic leakage (AL) in colorectal surgery is a complication feared by the increase in morbidity and mortality. The rate of AF is reported from 1 to 25%. Making the diagnosis early is difficult. OBJECTIVE: To determine the diagnostic performance of the C reactive protein (CRP) in a cohort of patients undergoing elective colorectal surgery with anastomosis. METHOD: A prospective, comparative study was conducted in 138 patients undergoing elective anastomosis with colorectal surgery, analyzing the serum values of CRP on postoperative days 1, 3, 5 and 7, as well as leukocytes and other abdominal sepsis data. RESULTS: The AL rate was 6.5%, the CRP values were significantly higher in the group of patients with AF on the 3rd postoperative day; with a cut-off point of 18.5 mg/dl on the third postoperative day, it obtained sensitivity 81%, specificity 91%, positive predictive value 45%, negative predictive value 98%. CONCLUSION: Measurement of CRP on the third postoperative day in patients undergoing elective colorectal surgery with primary or secondary anastomosis allows the identification of septic complications including leakage of anastomosis.

Colonic diverticulosis in an infant: A clue to total colonic Hirschsprung disease.

Total colonic aganglionosis is a rare phenotype of Hirschsprung disease (HD). While the diagnosis is generally established within the neonatal period there are reports of delayed presentation. In this case, we describe a 9-month old girl with no previous medical or surgical history who presented with a small bowel obstruction. A contrast enema performed as part of the work up demonstrated right sided colonic diverticula with no other anatomical abnormalities. Surgical intervention was required to manage the obstruction and colonic biopsies were consistent with HD. This case highlights the association of the unusual finding of colonic diverticula with total colonic HD in infants.

A proposal for a tailored approach to diverting ostomy for colorectal anastomosis.

BACKGROUND: The use of a protective stoma represents an important issue in colorectal surgery. Although evidence suggests that loop ileostomy may be superior, the optimal method for temporary decompression of colorectal anastomosis still remains controversial. Aim of this study was to make an evidence-based proposal for a tailored approach to the use of diverting colostomy or ileostomy. METHODS: A retrospective analysis of all patients subjected to creation and closure of a diverting loop colostomy or loop ileostomy between May 2007 and November 2014 in our institution was performed. Early and late complications, mortality and morbidity, time between formation and closure of the stoma in respect to adjuvant chemotherapy and the length of hospital stay were assessed and compared between the two groups. RESULTS: Outcomes of 167 patients (m=95; f=72) undergoing a loop colostomy (N.=130) or ileostomy (N.=37) were analyzed. The most frequent diagnosis was malignancy (64.1%), followed by abdominal emergency operations (18.6%) and complicated diverticular disease (17.4%). There was no mortality. Adjuvant chemotherapy (26.3%) resulted in delayed stoma reversal (P<0.001). Complications following construction of the stoma such as electrolyte disorder (P<0.001), renal insufficiency (P=0.048), and skin irritation (P=0.003) occurred significantly more often within the ileostomy group. Within the colostomy group, the rate of stoma prolapse (P=0.074) tended to be higher. CONCLUSIONS: Both methods have advantages and disadvantages. Loop transverse colostomy could be the preferred technique for older patients to avoid electrolyte disorder and renal insufficiency. Further prospective trials with documentation of electrolyte metabolism and quality of life should follow.

Manejo actual de la enfermedad diverticular aguda del colon / Current management of acute diverticular disease of the colon

Introducción: La colopatía diverticular es la enfermedad benigna más frecuente del colon, llegando a tener una incidencia del 70% a los 65 años de edad. El tratamiento fue variando a lo largo de los años. El objetivo de la presente monografía es realizar una recopilación de datos actualizados que permitan analizar las diferentes variables terapéuticas en relación al tratamiento médico y más específicamente quirúrgico de la enfermedad diverticular aguda. Materiales y Método: Se realizó una revisión bibliográfica actualizada en base a buscadores académicos médicos (PubMed, MedLine, Ovid, ResearchGate, Google Scholar, Lilacs, Rima, Cochrane) a partir de la cual se analizaron las diferentes variables relacionadas al tratamiento (manejo médico y quirúrgico). Resultados: Se desarrolló una guía de tratamiento en relación a la enfermedad diverticular complicada y no complicada y sus variables terapéuticas teniendo en cuenta la clasificación de HINCHEY. Conclusiones: La enfermedad diverticular tiene una incidencia en aumento en las últimas décadas, ya sea por un incremento en los factores de riesgo (dietas hipercalóricas, con un bajo contenido de fibras y verduras; obesidad; estrés) como por los avance en los métodos de diagnósticos, por lo que hay que saber diferenciar la terapéutica teniendo en cuenta no sólo la clasificación de HINCHEY sino también el estado general del paciente. En la mayoría de los casos no requerirá de una conducta quirúrgica para su resolución, siendo está indicada a los tipos III/IV y ante la falta de respuesta al tratamiento médico en los demás tipos. La elección de la técnica quirúrgica (Operación de Hartmann, Resección con anastomosis primaria con o sin ostomía de protección o lavado y drenaje de cavidad abdominal) se establecerá en base al estado general del paciente al momento del acto quirúrgico y a la experiencia del cirujano. (AU)

Plan de cuidados a paciente con enfermedad diverticular complicada / Care plan for patients with complicated diverticular disease

Se presenta el caso de un varón de 48 años, con diagnóstico de enfermedad diverticular complicada, que presenta sangrado recurrente posterior a la cirugía. La valoración enfermera se realiza teniendo como marco la Teoría del Autocuidado de Dorothea Orem. Se identificaron los factores condicionantes básicos y los requisitos de autocuidado universales del desarrollo y de desviación a la salud. Se utilizó el modelo de Análisis de Resultados del Estado Actual (AREA) y la taxonomía de la North American Nursing Diagnosis Association (NANDA), elaborándose un plan de cuidados considerando los resultados esperados y las intervenciones de Enfermería propuestas también en la Nursing Interventions Classification (NIC) y la Nursing Outcomes Classification (NOC). La aplicación del modelo AREA para el razonamiento clínico de Enfermería ayuda a priorizar los requisitos de autocuidado alterados del paciente, lo que permite identificar el diagnóstico enfermero principal, los diagnósticos secundarios y los diagnósticos de riesgo y, de esta forma, planificar los cuidados específicos para brindar una atención de salud integral (AU)

We hereby present the case of a 48-year-old male patient, with diagnosis of complicated diverticular disease, presenting recurrent postsurgical bleeding. Nursing evaluation was conducted within the setting of the Dorothea Orem's Self-Care Theory. Basic determining factors were identified, as well as universal self-care requirements for development and health deviation. The study used the model from the Analysis of Current Status Outcomes (ACSO), and the taxonomy by the North American Nursing Diagnosis Association (NANDA); the care plan was prepared considering the expected outcomes and the nursing interventions also put forward by the Nursing Interventions Classification (NIC) and the Nursing Outcomes Classification (NOC). The application of the ACSO model for the clinical rationale of Nursing allows to prioritize the altered self-care requirements of the patient, which facilitates the identification of the primary Nursing diagnosis, secondary diagnoses and risk diagnoses, and therefore, to plan the specific care in order to offer comprehensive patient care (AU)

Foreign bodies in sigmoid colon diverticulosis.

This review addresses the management of sigmoid colon diverticular disease associated with foreign bodies. In addition, two novel cases are presented. One case describes the management of diverticular bleeding secondary to a chicken bone and the other case reports retrieval of a retained EndoRings™ Device. The review identified 40 relevant publications including 50 subjects. Foreign bodies within sigmoid diverticular disease may be associated with inflammation, perforation, abscess and fistula. In current practice, diagnosis is often achieved with CT scan. Patients with colonic perforation or fistula generally require colonic resection. Patients with inflammation may merit conservative management, including colonoscopic foreign body retrieval. Chicken bones, tooth picks, and biliary stents have been reported in patients with inflammation, perforation and fistula, whereas all published patients with fish bone related diverticulosis complications experienced inflammation. Treatment might be best guided by the consequences of the foreign body rather than the nature of the underlying retained object. Diverticular bleeding secondary to a chicken bone was diagnosed at CT angiography and treated with colonoscopic snare retrieval of the bone and clipping of the bleeding diverticulum. The EndoRings™ Device was retrieved with a colonoscopic balloon.

Segmental colectomy for bleeding diverticular disease guided by the PEEP test.

Many patients with massive lower gastrointestinal (GI) haemorrhage from diverticulosis are subjected to total colectomy when preoperative localisation is unavailable. We dissected colectomy specimens and noted that there was limited retrograde reflux in most of these cases. Therefore, we sought to assess the value of a positive endoluminal erythrocyte presence (PEEP) test (presence of fresh blood in the caecum) to direct segmental colectomies in 14 patients who required emergency operations for massive lower GI haemorrhage. Overall, 13 (93%) patients who had segmental colectomy guided by the PEEP test had successful control of bleeding. There was no mortality and a 14% postoperative morbidity after segmental resections guided by the PEEP test. One patient had persistent bleeding and required a completion colectomy on the third postoperative day. We propose that the PEEP test be added to the surgical armamentarium to guide segmental resection in the absence of localisation by conventional means. However, we advocate blind total colectomy if the PEEP test is equivocal and early completion colectomy if there is significant re-bleeding.

Colonic Diverticulosis and Diverticulitis in Renal Transplant Recipients: Management and Long-Term Outcomes.

Data regarding management of colonic diverticulitis in renal transplant recipients (RTRs) are limited. This study aims to identify prevalence, risk factors, and outcomes in RTRs with colonic diverticulosis and diverticulitis. Between January 2004 and December 2013, all patients who underwent kidney transplantation were analyzed. Among all RTSs, patients who had a pretransplant colonoscopic diagnosis of diverticulosis and patients with a proven attack of diverticulitis were included in our analysis. There were 1578 RTRs with a mean age of 50 ± 14 years at the time of transplantation. Of these, 409 patients had colonoscopic evaluation and 174 (43%) were diagnosed with diverticular disease. Fifteen (0.9%) out of 1578 developed a primary attack of diverticulitis. Two patients underwent a Hartmann's procedure due to perforation. Among 13 patients who were initially treated nonoperatively, 4 required surgery due to refractory diverticulitis (n = 2) and recurrence (n = 2). Tobacco use (59% vs 48%, P = 0.02), increased age (58 vs 51 years, P < 0.0001), diabetes (33% vs 35%, P = 0.03), coronary artery disease (38% vs 22%, P = 0.001), and autosomal dominant polycystic kidney disease etiology (P = 0.04) were more common in RTRs with diverticulosis. Majority of RTRs with diverticulitis can be managed nonoperatively. Surgical treatment is warranted in patients with perforated, persistent, and recurrent diverticulitis. A special care and follow-up may be needed in RTRs with autosomal dominant polycystic kidney disease etiology, smoking history, and coronary artery disease due to higher risk of diverticulosis and subsequent potential diverticulitis.